Children

Haemophilia A is commonly diagnosed at a young age, with severe haemophilia A often identified in the days following birth. During childhood, a highly effective, reliable treatment is essential.1

The World Federation of Hemophilia Guidelines highlight the importance of prophylaxis for children for the reduction of bleeding episodes.2 Prophylaxis is important for long-term health,2 as starting prophylaxis early has been shown to limit joint damage later in life.3

The efficacy of Nuwiq® (simoctocog alfa) has been demonstrated in prospective clinical trials in children of all ages with an established safety and tolerability profile.4,5

simoctocog-img

All-round efficacy of Nuwiq® (simoctocog alfa)

has been demonstrated in prospective clinical trials in children of all ages

Efficacy of prophylaxis with Nuwiq® in children

In previously treated children who
received long-term Nuwiq® prophylaxis for
a median of 2 years4
Median annualised bleeding rate
(ABR) for spontaneous bleeds
(n=47)
Had a dosing frequency of ≤2x/week
(n=33)
In previously untreated
children on continuous Nuwiq®
prophylaxis for ≥6 months4
Median ABR for
spontaneous bleeds
(n=50)
of 305 bleed treatments were rated as
excellent or good in children treated
with Nuwiq®6
In previously treated children
undergoing surgery, all 21 rated
surgeries were managed
successfully6
Efficacy was rated “excellent” for all
procedures with documented
efficacy assessments
In previously treated children who
received long-term Nuwiq® prophylaxis for
a median of 2 years4
Median annualised bleeding rate
(ABR) for spontaneous bleeds
(n=47)
Had a dosing frequency of ≤2x/week
(n=33)
In previously untreated
children on continuous Nuwiq®
prophylaxis for ≥6 months4
Median ABR for
spontaneous bleeds
(n=50)
of 305 bleed treatments were rated as
excellent or good in children treated
with Nuwiq®6
In previously treated children
undergoing surgery, all 21 rated
surgeries were managed
successfully6
Efficacy was rated “excellent” for all
procedures with documented
efficacy assessments

Nuwiq® in children

Early steps in life’s journey for people with severe haemophilia A

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Nuwiq® safety and tolerability profile

is well-established in children

In children who received long-term Nuwiq® prophylaxis for a median of 2 years and as considered by the investigators4

In clinical trials with Nuwiq® in children6-7

reported in previously treated children who switched to Nuwiq® 6, 8

References

  • 1

    Bertamino M et al. J Clin Med 2017; 6:54;​

  • 2

    Srivastava A et al. Haemophilia 2020; 26(Suppl. 6):1-158;​

  • 3

    Manco-Johnson MJ et al. N Engl J Med 2007; 357:535-44;​

  • 4

    Mathias M et al. Haemophilia 2023; 29:1005-12;​

  • 5

    Liesner RJ and Neufeld EJ. Blood 2019; 134(Suppl.1):903;​

  • 6

    Klukowska A et al. Haemophilia 2018; 24:595-603;​

  • 7

    Klukowska A et al. Ther Adv Hematol 2024; 15:20406207241245511;​

  • 8

    Lissitchkov T et al. Ther Adv Hematol 2019; 10:2040620719858471.

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